If human skeletal remains are found, which DNA technique is most appropriate for victim identification?

Mitochondrial DNA (mtDNA) analysis is particularly suitable for victim identification from human skeletal remains due to the unique properties of mtDNA. Unlike nuclear DNA, which is present in both parents and can be more degraded in older or fragmented skeletal remains, mtDNA is inherited maternally and is more abundant within cells. This makes it an advantageous method in forensic contexts where samples may be compromised or where only minimal biological material is available.

The ability of mtDNA to survive in degraded states is critical in forensic science, especially when dealing with ancient remains or in situations where the skeletal remains have been subject to environmental factors that can damage nuclear DNA. In many cases, mtDNA provides a viable option to establish familial relationships, which can be crucial in identifying victims, particularly in mass disaster scenarios or historical investigations.

Additionally, the comparative ease of extraction and amplification of mtDNA further supports its use in forensic identification. Given these attributes, mtDNA analysis stands out as a reliable method for victim identification when working with skeletal remains.